약물전달능을 지닌 생체활성 실리카젤과 폴리카프로락톤(PCL)을 복합화한 마이크로입자의 제조
Fabrication of Bioactive Silica Gel-Polycaprolactone Hybrid Microparticles Capable of Drug Delivery
박종섭,
소속 상세정보
박종섭 ( Park Jong-Sup ) - 단국대학교 치과대학 구강해부학교실
KMID : 0362220110380030233
Abstract
Bioactive ceramic-polymer hybrid microparticles were fabricated and examined for drug delivery capability in this study. Particulated silica gel synthesized via sol-gel method was used for ceramic component, and biodegradable polycaprolactone was used as polymer matrix. Amount of silica gel particles against matrix was fixed in 30 wt% to be well dispersed in the composite, resulting in formation of microparticles. Average size of the hybrid particles synthesized was about 385 ㎛. Bioactivity of the hybrid material was confirmed by hydroxyapatite layer formed on the surface of microparticles after soaking in simulated body fluid. Tetracycline was incorporate in the hybrid microparticles to evaluate capability of drug delivery in phosphate buffered solution. Tetracycline socked in the microparticles was released slowly about 55% up to 4 weeks. From the results, the silica gel-polycaprolactone hybrid microparticles can be used for potential
carrier for drug delivery and regeneration of bone.
키워드
Bone regeneration;Drug delivery system;Microparticles;Polycaprolactone;Silica-gel
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